灯盏花注射液对大鼠慢性低氧性心肌损伤的预防作用

doi:10.3736/jcim20040212

Abstract

Objective: To study the preventive effect of Breviscapus Injection on the chronic hypoxic myocardium injury in rats and its mechanism. Methods: Transmission electron microscope and biochemical analysis were used to assay the therapeutic effect of Breviscapus Injection in rat model induced by 4 week's hypoxia. Results: The contents of malondialdehyde(MDA) and Ca ²⁺ in the homogenate of myocardial tissue of the hypoxic rats were significantly higher than those of the control rats. The activities of superoxide dismutase(SOD), nitric oxide synthase (NOS) in the homogenate of myocardial tissue and the plasmic NO levels of the hypoxic rats were significantly lower than those of the control rats. Breviscapus Injection reduced the contents of MDA and Ca ²⁺, and increased the levels of SOD, NOS and NO. Ultrastructural examination revealed that the injuries of the ultrastructure of heart in hypoxic rats were improved by treatment with Breviscapus Injection. Conclusion: Breviscapus Injection can effectively prevent and treat the hypoxia-induced myocardial damage. One of its mechanisms may relate to its adjusting NO level, anti-damaging of free radicals and inhibiting calcium overload.

Key words: Breviscapus Injection, myocardial protection, animals, laboratory

CLC Number:

R542.2

Sun-zhong Mao, Zhe Yan, Yu-peng Xie. Preventive effect of Breviscapus Injection on chronic hypoxic myocardium injury in rats. Journal of Chinese Integrative Medicine, 2004, 2(2): 117-119.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040212

http://www.jcimjournal.com/EN/Y2004/V2/I2/117

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References 6

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Group	n	SOD(U/mg pro)	MDA(μmol/g pro)	Ca²⁺ (μmol/g pro)
Control	10	589±86	3.7±1.2	6.3±2.1
Hypoxic rats	10	433±64**	7.7±1.8**	15.3±4.4**
Breviscapus Injection	10	504±75^△*	5.6±1.5^△*	8.0±1.7^△△

Group	n	NOS(U/mg pro)	NO(μmol/L)
Control	10	10.18±0.49	34.3±6.5
Hypoxic rats	10	8.21±0.44**	27.6±2.1*
Breviscapus Injection	10	9.41±0.27^△	30.7±2.1

Preventive effect of Breviscapus Injection on chronic hypoxic myocardium injury in rats

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