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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (2): 132-134.doi: 10.3736/jcim20040217

• Technique and Methods • Previous Articles     Next Articles

Comparison of animal models of hyperlipidemia

Xue-mei Liu, Fu-huo Wu   

  1. Department of Pharmacology for Chinese Materia Medica,Fujian College of Traditional Chinese Medicine, Fuzhou, Fujian Province 350003, China
  • Online:2004-03-20 Published:2018-10-25

Objective: To select the proper experimental animal model for research on prevention and treatment of hyperlipidemia.Methods: Hyperlipidemia models of mouse, rat, golden hamster, guinea pig, rabbit, pigeon and quail often used in the last ten years were compared.Results: Golden hamster and guinea pig models are similar to human beings in lipid metabolism and have unique superiority in experimental study, while the models of rat, mouse, pigeon and quail have significant difference as compared with human beings. Rabbit is one of the best animal models in studying new drugs for regulating lipid and treating arteriosclerosis.Conclusion: Factors such as the required time, indexes, the duration of making models, and the cost and feeding of animals should be considered in selecting animal models according with the experimental requirements.

Key words: experimental animal models, hyperlipidemia, comparative

CLC Number: 

  • R-332
[1] Kris-Etherton PM, Dietschy J . Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors:human and animal studies[J]. Am J Clin Nutr, 1997,65(5 Suppl):1590S-1596S
[2] Shefer S, Nguyen LB, Salen G , et al. Differing effects of cholesterol and taurocholate on steady state hepatic HMG-CoA reductase and cholesterol 7 alpha-hydroxylase activities and mRNA levels in the rat[J]. J Lipid Res, 1992,33(8):1193-1200
[3] 刘明, 董超仁, 苏静怡 . 一种简便实用的大鼠高脂血症模型[J]. 中国药理学通报, 1989,5(2):119-120
[4] 杨万章, 万中民, 权志博 . 一种简易大鼠高脂血症模型[J]. 甘肃中医学院学报, 1996,13(2):52-53
[5] 刘凯, 李传富, 申冬珠 . 大鼠高胆固醇血症快速造型法初筛降脂中草药[J]. 徐州医学院学报, 1990,10(4):260-262
[6] 王禄增, 张梅英, 季勇 , 等. Wistar大鼠实验性动脉粥样硬化的研究[J]. 中国实验动物学报, 2002,10(2):113-115
doi: 10.3969/j.issn.1005-4847.2002.02.012
[7] 杨小毅, 杨永宗, 谭健苗 , 等. 一种纯系小鼠动脉粥样硬化病理模型的建立[J]. 中国动脉硬化杂志, 1996,4(1):54-57
[8] 余艳辉, 文军, 郭兆贵 . Triton WR-1339对小鼠血脂水平的影响[J]. 中国药理学通报, 2002,18(5):599-600
doi: 10.3321/j.issn:1001-1978.2002.05.036
[9] Shimano H, Yamada N, Katsuki M , et al. Overexpression of apolipoprotein E in transgenic mice:marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia[J]. Proc Natl Acad Sci U S A, 1992,89(5):1750-1754
[10] 唐世英, 胡桂才, 李可基 , 等. 金黄地鼠高脂血症动物模型的应用研究[J]. 承德医学院学报, 2002,19(3):173-175
doi: 10.3969/j.issn.1004-6879.2002.03.001
[11] 高莹, 李可基, 唐世英 , 等. 几种高脂血症动物模型的比较[J]. 卫生研究, 2002,31(2):97-99
doi: 10.3969/j.issn.1000-8020.2002.02.015
[12] Harris WS . n-3 fatty acids and serum lipoproteins: animal studies[J]. Am J Clin Nutr, 1997,65(5 Suppl):1611S-1616S
doi: 10.1016/S0271-5317(97)00070-5 pmid: 9129504
[13] 李文雄, 曲丽芳, 冯雪梅 , 等. 中药复方对实验性老年高脂血症LPO、SOD和红细胞免疫功能的影响[J]. 成都中医药大学学报, 1997,20(3):48-50
[14] H.G. 沃格尔主编, 杜冠华, 李学军, 张永祥, 等译. 药理学实验指南——新药发现和药理学评价(第1版)[M]. 北京: 科学出版社, 2001,( 第1版):777
[15] 朱燕, 李长龄, 王银叶 . 血脂康对高脂家兔、鹌鹑模型的降脂作用[J]. 中国药学杂志, 1995,30(11):656-658
[16] 张勇, 娄桂予, 钱民章 . 建立兔高脂血症模型及动脉粥样硬化斑块的方法[J]. 遵义医学院学报, 2001,24(4):304-306
doi: 10.3969/j.issn.1000-2715.2001.04.002
[17] 王文健, 费震宇, 傅晓东 , 等. 家兔绝经后动脉粥样硬化模型的建立及补肾治疗对其的影响[J]. 中西医结合学报, 2003,1(2):113-115
Wang WJ, Fei ZY, Fu XD , et al. Study of an animal model of post-menopausal atherosclerosis in rabbit and observation of the effect of herbal formula of tonifying-kidney on it[J]. Zhong Xi Yi Jie He Xue Bao, 2003,1(2):113-115
[18] Fernandez ML, Vergara-Jimenez M, Conde K , et al. Regulation of apolipoprotein B-containing lipoproteins by dietary soluble fiber in guinea pigs[J]. Am J Clin Nutr, 1997,65(3):814-822
doi: 10.1016/S0271-5317(97)00044-4 pmid: 9062534
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