马齿苋对D-半乳糖衰老模型小鼠应激能力的影响

doi:10.3736/jcim20040515

Abstract

Objective: To investigate the effects of purslane herb aquenous extracts (PHAS) on the stress ability of aging mice induced by D-galactose.Methods: We odserved the survival time to hypoxia and heat survival rate of the mice treated with different doses of PHAS and vitamin E. The contents of lipofuscin and malondialdehyde (MDA), and the activity of superoxide dismutase (SOD) and catalase (CAT) in the brain and liver of the mice were tested.Results: As compared with vitamin E, three doses of PHAS (1.6, 0.8 and 0.4 ml/d) prolonged the survival time to hypoxia and the pole climbing time and increased the heat survival rate, and the 0.8 ml/d PHAS had the best effect.In the group of 0.8 ml/d PHAS, the activity of SOD and CAT decreased less, and the contents of lipofuscin and MDA decreased significantly.The effect of vitamin E was not as good as the PHAS.Conclusion: PHAS can prevent the stress ability of the aging mice.One of its mechanisms may be increasing the activity of SOD and CAT, hence decreasing the damage of the oxidation products to the body.

Key words: purslane herb, aging, stress, antioxidation

CLC Number:

R283.1

Chen Ling. Effects of purslane herb on stress ability of aging mice induced by D-galactose. Journal of Chinese Integrative Medicine, 2004, 2(5): 361-363.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040515

http://www.jcimjournal.com/EN/Y2004/V2/I5/361

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Group	Pole climbing time (n=30,$\bar{x}$±s, min)	Survival time to hypoxia (n=10,$\bar{x}$±s, min)	Heat survival rate (n=10, %)
Normal mice	20.5±4.3	18.2±2.8	100
Aging mice	12.0±2.5^{* *}	16.0±1.7^*	10
Vitamin E	15.8±3.3^*	15.2±2.0^*	20
High dose purslane herb	21.0±5.1 ^▲▲	19.2±1.8^▲▲	80
Middle dose purslane herb	22.7±5.3 ^▲▲	21.5±2.2^▲▲	80
Low dose purslanc herb	18.8±4.0^▲▲	18.7±2.3^▲	50

Group	n	SOD (nU/mg pro)		CAT
Group	n	Cerebral cortex	Liver	Blood (U/g Hb)	Liver (U/mg pro)
Normal mice	10	82.3±16.8	102.2±45.8	83.7±9.3	272.1±43.2
Aging mice	10	62.5±19.6^{* *}	60.1±26.9^*	69.5±10.6^{* *}	239.6±48.0
Vitamin E	10	71.5±16.3	78.8±25.4	71.2±10.5^{* *}	245.7±34.6
High dose purslane herb	10	78.6±9.2	89.6±27.7	83.0±4.3^▲▲	305.8±34.6^▲▲
Middle dose purslane herb	10	81.6±18.9^▲	92.6±22.8^▲	87.9±5.4^▲▲	265.7±30.6
Low dose purslane herb	10	75.0±14.7	82.4±21.3	85.7±5.1^▲▲	241.7±27.3

Group	n	Lipofusin (fluorescent reading number)		MDA (nmol/mg pro)
Group	n	Cerebral cortex	Liver	Cerebral cortex	Liver
Normal mice	10	65.7±3.6	4.2±0.7	3.2±0.8	1.1±0.3
Aging mice	10	75.2±6.3	5.2±0.3	5.6±1.1	1.5±0.4
Vitamin E	10	69.6±6.9	4.7±0.3	4.6±0.3	0.9±0.3
High dose purslane herb	10	66.9±7.7^▲	4.8±0.5	3.2±0.8	1.2±0.3
Middle dose purslane herb	10	69.5±7.1	4.5±0.6	4.0±0.6	1.1±0.2^▲
Low dose purslane herb	10	74.0±4.8	4.7±0.8	4.4±1.0	1.3±0.3

Effects of purslane herb on stress ability of aging mice induced by D-galactose

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