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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (6): 446-449.doi: 10.3736/jcim20050607

• Original Clinical Research • Previous Articles     Next Articles

Immunological mechanism of exfoliative tongue fur in children with asthma

Fu-feng Li1,Guo-gang Li1,You-zhong Wu1,Jing Li1,Xiao-ying Zhang2,Hui-fang Wang1,Yi-qin Wang1   

  1. 1. Laboratory of Syndromes of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. Central Laboratory, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China
  • Received:2005-03-10 Online:2005-11-20 Published:2005-11-20
  • Contact: Fu-feng Li E-mail:fufeng_lee@hotmail.com

Objective

To explore the immunological mechanism of exfoliative tongue fur in children with asthma.

Methods

Thirty-nine children with asthma, twenty-eight children with repetitive respiratory tract infection (non-asthma) and eleven healthy children were divided into five groups, which were asthma with exfoliative fur or with non-exfoliative fur groups, non-asthma with exfoliative fur or with non-exfoliative fur groups and normal control group. The concentrations of keratin 13 and bcl-2 in cells exfoliated from tongue fur were detected by immunohistochemical method. The expression levels of blood cell chemokine receptor-3 (CCR-3) and CD4 + were examined by flow cytometry, and the levels of serum cortisol and IgE were detected by radioimmunoassay.

Results

The levels of blood CD4 + and CCR-3 of children with asthma and exfoliative fur were higher than those in the asthma with non-exfoliative fur group and the normal control group (P<0.05). The serum level of cortisol in the groups of asthma with exfoliative fur and non-asthma with exfoliative fur were lower than that in the other groups (P<0.05). The serum levels of IgE in asthma with exfoliative fur or with non-exfoliative fur groups were higher than that in the other groups (P<0.05). Concentrations of keratin 13 in the cells exfoliated from tongue fur in the groups of asthma or non-asthma with exfoliative fur were lower than that of the other groups (P<0.05). There was no significant difference of expression level of bcl-2 in the cells exfoliated from tongue fur among these five groups.

Conclusion

There is a reasonably close relationship between the formation of exfoliative tongue fur and the immune system such as low level of serum cortisol and high levels of blood CD4 + and CCR-3, which may all promote the formation of exfoliative fur. The disability of keratinization and apoptosis of epithelial cells of tongue may also be one cause for its formation.

Key words: Exfoliative fur, Asthma, Immunity

CLC Number: 

  • R241.25

Tab 1

Serum levels of IgE and cortisol in 5 groups of children ($\bar{x}$±s )"

Group n IgE (kU/L) Cortisol (μg/L)
Asthma
with exfoliative fur 18 769.73±283.84*△□ 150.5±72.3*▲□
with non-exfoliative fur 21 770.36±317.50*△□ 190.5±69.5
Non-asthma
with exfoliative fur 14 532.79±398.60 175.7±65.3*▲□
with non-exfoliative fur 14 612.30±390.24 221.1±107.6
Normal control 11 548.16±252.53 223.4±35.6

Tab 2

Blood levels of CCR-3 and CD4+ in 5 groups of children ($\bar{x}$±s ,%)"

Group n CCR-3 CD4+
Asthma
with exfoliative fur 18 3.76±2.62*△□ 41.59±6.63*△▲□
with non-exfoliative fur 21 4.30±3.62*△□ 31.39±7.28
Non-asthma
with exfoliative fur 14 2.45±1.19 35.72±4.85
with non-exfoliative fur 14 2.74±2.25 32.99±10.10
Normal control 11 2.43±0.76 30.16±7.53

Tab 3

Expressions of keratin 13 and bcl-2 in cells exfoliated from tongue fur of children in 5 groups ($\bar{x}$±s )"

Group n keratin 13 bcl-2
Asthma
with exfoliative fur 18 18.32±15.24*△▲□ 67.62±32.08
with non-exfoliative fur 21 25.55±18.15* 75.73±31.32
Non-asthma
with exfoliative fur 14 17.96±14.23*△□ 72.82±39.06
with non-exfoliative fur 14 41.19±24.01 74.53±26.86
Normal control 11 38.75±13.25 72.31±23.21
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